AEBP2 — AE binding protein 2
AEBP2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AEBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ARID1B, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS, GLS +18 more |
About the gene
| Synonyms | MGC17922 |
|---|---|
| Chromosome | 12: 19404045-19720801 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.