Chromatin Epigenetic Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub genes ARID1B (SWI/SNF BAF complex), AEBP2 (PRC2 accessory), SMCHD1 (chromatin silencing), UHRF2 (epigenetic reader/writer), and FBRS (chromatin-associated) collectively define a chromatin remodeling and epigenetic regulation program. STIM2 (calcium store sensor) and ATG12 (autophagy) are peripheral members. Neighbor M172 also features chromatin remodelers (KDM6A, CHD6), supporting a shared chromatin regulation neighborhood. Module coherence is moderate, suggesting some admixture, but chromatin/epigenetic regulation dominates.
Genes
AEBP2, ARID1B, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS, GLS, GOLPH3, GOLT1B, HECTD4, ITSN2, NPLOC4, PARP12, PTPRJ, R3HDM2, RAB11FIP4, RBMS1, RNF169, SEC24B, SMCHD1, STIM2, TMEM248, UHRF2, WDR82, WHAMM
Most correlated modules
- MAPK Kinase Signaling · correlation 0.87
- Histone Demethylase Program · correlation 0.85
- T Cell Maturation · correlation 0.84
- mRNA Splicing Processing · correlation 0.83
- Osmotic Stress Response · correlation 0.82
- T Cell Exhaustion · correlation 0.82
- Transcriptional Coactivation · correlation 0.82
- Stress Epigenetic Silencing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.