GLS — Glutaminase

GLS belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GLS's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Antiviral Restriction Anti-viral	FCRL1, PPM1K, SP100, SP140L, STAT3, TGFB1, TSC22D2, WSB1 +1 more	View in SCUBA
CD4⁺ T cells	mRNA Splicing Factors RNA processing	ARGLU1, CDKN2D, CLK1, ERO1B, FUS, HNRNPA2B1, ID1, MAT2A +8 more	View in SCUBA
Fibroblasts	Chromatin Transcriptional Regulation Developmental	BRD2, C6orf62, CBX4, KLHL15, LSMEM1, MKNK2, NUFIP2, NXF1 +4 more	View in SCUBA
Gamma-delta T cells	Chromatin Epigenetic Regulation DNA/chromatin regulation	AEBP2, ARID1B, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS +18 more
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT3, DDIT4, ID1, IFRD1, INTS6, JMJD6, KLF4 +9 more	View in SCUBA
Macrophages	Post-transcriptional Regulation Housekeeping	AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more	View in SCUBA
Mucosal-associated invariant T cell	TCR Activation Signaling TCR Signaling	ARFGEF1, ARIH1, CARD11, CCDC88C, CD226, KANSL1, KMT5B, MAP3K2 +12 more
Smooth muscle cells	BMP/TGF-beta response Activation	APBB2, ID1, ID2, IRS2, KLF10, RND3, SEC11C, SIPA1L2 +1 more	View in SCUBA

About the gene

Synonyms	GAC, GAM, GLS1, KGA, KIAA0838
Chromosome	2: 190880821-190965552
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Lacks catalytic activity

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.