ARID1B — AT-rich interaction domain 1B
ARID1B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARID1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin & genome maintenance DNA/chromatin regulation | ASH1L, ATM, ATRX, BOD1L1, DDX17, KANSL1, MARF1, NKTR +8 more | View in SCUBA |
| CD4⁺ T cells | Epigenetic regulation DNA/chromatin regulation | AFF4, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP, TET2 +6 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | AEBP2, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS, GLS +18 more | |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ADI1, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2, MPC2 +10 more | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARK2N, ASAP1, ATF6, ATP11A, CDC73 +48 more | View in SCUBA |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID2, ATP8A1, ATXN1, BRAF, CCSER2, CDC42SE2 +13 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8, PHIP +5 more |
About the gene
| Synonyms | 6A3-5, BAF250b, DAN15, ELD/OSA1, KIAA1235, p250R, SMARCF2 |
|---|---|
| Chromosome | 6: 156776020-157210779 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non- specifically.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.