AGT — Angiotensinogen
AGT belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Thrombin Receptor Signaling Inflammatory | ADAMTS9, CDCP1, CDH13, EFCC1, EPS8, F2R, F2RL2, FAM89A +10 more | View in SCUBA |
About the gene
| Synonyms | SERPINA8 |
|---|---|
| Chromosome | 1: 230690776-230745576 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Vasoactive, Vasoconstrictor |
Function
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor (By similarity). Stimulates aldosterone release. Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.