ADAMTS9 — ADAM metallopeptidase with thrombospondin type 1 motif 9
ADAMTS9 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Chronic Inflammatory Activation Inflammation | ABL2, DDX21, EMP1, FOSL2, HRH1, KRT10, LMNA, PNP +2 more | View in SCUBA |
| Fibroblasts | Thrombin Receptor Signaling Inflammatory | AGT, CDCP1, CDH13, EFCC1, EPS8, F2R, F2RL2, FAM89A +10 more | View in SCUBA |
| Pericytes | NF-κB Inflammatory Response Inflammatory | ABL2, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, KLF10, PIM3 +3 more | View in SCUBA |
| Smooth muscle cells | NR4A-ADAMTS Activation Stress | ADAMTS1, ADAMTS4, AVPR1A, DUSP8, HIPK2, KLF9, MYC, NR4A1 +5 more | View in SCUBA |
About the gene
| Synonyms | KIAA1312 |
|---|---|
| Chromosome | 3: 64515654-64688000 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.