Thrombin Receptor Signaling
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes F2R and F2RL2 are protease-activated receptors (PARs) responding to thrombin/coagulation proteases; AGT (angiotensinogen) is a vasoactive peptide precursor; TRPA1 is a nociceptive/inflammatory channel; ADAMTS9 is an ECM-remodeling protease. Together these genes define a coagulation/thrombin receptor signaling program in intestinal fibroblasts, upregulated significantly in UC inflammation. CDH13 and SMOC1 are peripheral ECM/adhesion members.
Genes
ADAMTS9, AGT, CDCP1, CDH13, EFCC1, EPS8, F2R, F2RL2, FAM89A, FSD1L, HIPK2, KBTBD11, MAN2A1, MPHOSPH6, PTPRE, RGS17, SMOC1, TRAC, TRPA1
Most correlated modules
- IL-1 Receptor Signaling · correlation 0.88
- Myofibroblast Subtype · correlation 0.85
- WNT-modulating Fibroblast · correlation 0.85
- Inflammatory Fibroblast Activation · correlation 0.82
- TGF-beta Fibrosis · correlation 0.81
- Wnt-BMP Fibroblast · correlation 0.81
- Basement Membrane ECM · correlation 0.80
- Metabolic Homeostasis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.