ARHGEF16 — Rho guanine nucleotide exchange factor 16
ARHGEF16 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF16's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Membrane Cytoskeletal Remodeling Cytoskeletal | ANO9, DNM2, LRCH4, MICALL2, MROH6, PHYKPL, PIGQ, SHROOM1 +2 more | View in SCUBA |
About the gene
| Synonyms | GEF16, NBR |
|---|---|
| Chromosome | 1: 3454665-3481113 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.