LRCH4 — Leucine rich repeats and calponin homology domain containing 4
LRCH4 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRCH4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Membrane Cytoskeletal Remodeling Cytoskeletal | ANO9, ARHGEF16, DNM2, MICALL2, MROH6, PHYKPL, PIGQ, SHROOM1 +2 more | View in SCUBA |
About the gene
| Synonyms | LRN, LRRN1 |
|---|---|
| Chromosome | 7: 100574011-100586129 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.