PHYKPL — 5-phosphohydroxy-L-lysine phospho-lyase
PHYKPL belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHYKPL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lymphoid signaling regulators BCR/AP1/NFKb pathway | CCDC88B, FGD2, IKZF1, LENG8, MACF1, OGT, PCSK7, PNISR +4 more | View in SCUBA |
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1 +10 more | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | ATIC, CD244, CYTH4, EIF2S2, GPR68, GSDMD, ING4, KEAP1 +11 more | |
| Natural Killer cells | NK Tissue Residency Gut residency | ENTPD1, GEM, GPR171, ITGA1, KLHL23, LDLRAD4, RCAN3 | View in SCUBA |
About the gene
| Synonyms | AGXT2L2, MGC15875 |
|---|---|
| Chromosome | 5: 178208471-178232802 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Lyase |
Function
Catalyzes the pyridoxal-phosphate-dependent breakdown of 5- phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.