Membrane Cytoskeletal Remodeling
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include DNM2 (dynamin-2, membrane fission and endocytosis), MICALL2 (Rab-interacting protein, vesicle trafficking), ANO9 (anoctamin calcium-activated chloride channel, membrane dynamics), ARHGEF16 (Rho GEF regulating actin/membrane), SHROOM1 (actin cytoskeleton organization). TMEM184A is a transmembrane protein. URGCP and LRCH4 have roles in cytoskeletal regulation. The module is strongly inflammation-associated (delta_inflammation 0.697, significant in both UC and CD). The combination of Rho GEF, dynamin, and actin regulators points to membrane/cytoskeletal remodeling in inflamed colonocytes. Neighbor M63 (senescence/cytoskeletal) supports a cytoskeletal remodeling theme in this neighborhood.
Genes
Most correlated modules
- Colonocyte Cytoskeletal Contractility · correlation 0.89
- Lipid Metabolism · correlation 0.84
- Transcriptional Golgi Remodeling · correlation 0.83
- Colonocyte Senescence · correlation 0.82
- Inflammatory Colonocyte State · correlation 0.69
- Lipid Xenobiotic Metabolism · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.