ATOH1 — Atonal bHLH transcription factor 1
ATOH1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATOH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Secretory Lineage Specification Epithelial development | ANXA13, CA8, CBFA2T2, DLL1, DYRK4, FOXA2, FRA10AC1, GSE1 +12 more | View in SCUBA |
About the gene
| Synonyms | bHLHa14, HATH1, MATH-1, Math1 |
|---|---|
| Chromosome | 4: 93828753-93830964 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Function
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.