Goblet cells: gene co-expression modules

Secretory epithelial cells packed with mucin granules; they build the layered mucus barrier, deliver antigen to dendritic cells, and release trefoil peptides that support epithelial repair.

SCUBA's reference network for Goblet cells holds 99 gene modules covering 1,112 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Goblet cells network in SCUBA

Cell cycle (9)

• Chromosome Segregation · 12 genes
• FOXM1-driven G2/M · 14 genes
• G2/M Cyclin Program · 14 genes
• MCM Replication Licensing · 13 genes
• Mitotic Proliferation · 8 genes
• Mitotic Spindle Assembly · 14 genes
• Replication Fork Checkpoint · 9 genes
• S-phase DNA Replication · 10 genes
• S/G2 Preparation · 13 genes

chromatin regulation & transcription (9)

• Chromatin Organization · 8 genes
• Chromatin Remodeling · 9 genes
• Chromatin Remodeling · 11 genes
• Chromatin Remodeling Repair · 10 genes
• Chromatin RNA Regulation · 10 genes
• Immediate Early Gene · 9 genes
• NF-kB Inflammatory Signaling · 14 genes
• Nuclear Architecture · 12 genes
• Stress Chromatin Remodeling · 10 genes

Cytoskeletal (3)

• Actin Cytoskeletal Remodeling · 12 genes
• Actin Dynamics · 12 genes
• Adhesion & Transport · 13 genes

Epithelial development (13)

• BMP Signaling Response · 9 genes
• Colonocyte Differentiation Program · 17 genes
• EGF-Driven Wound Repair · 10 genes
• Epithelial Differentiation Metabolism · 8 genes
• Epithelial Maturation · 11 genes
• Epithelial Membrane Identity · 10 genes
• Goblet Cell Differentiation · 9 genes
• Goblet Cell Identity · 14 genes
• Mature Colonocyte Function · 11 genes
• Notch Secretory Specification · 13 genes
• Notch Target Response · 8 genes
• Progenitor Identity Program · 12 genes
• Secretory Lineage Specification · 21 genes

Housekeeping (9)

• Anti-inflammatory Lipid Signaling · 8 genes
• Basal Transcription · 11 genes
• Epithelial Maintenance · 8 genes
• Ion Transport Homeostasis · 9 genes
• Lipid Redox Homeostasis · 9 genes
• Proteostasis Housekeeping · 13 genes
• Sterol Biosynthesis · 8 genes
• Ubiquitin Protein Homeostasis · 15 genes
• Ubiquitin-Proteasome Degradation · 9 genes

Immune function (6)

• Inflammatory goblet response · 17 genes
• MHC Class I Antigen Presentation · 13 genes
• MHC Class II Antigen Presentation · 11 genes
• Mucosal Antibacterial Defense · 17 genes
• Mucosal Innate Defense · 13 genes
• Secreted Antimicrobials · 15 genes

migration & adhesion (2)

• Basement Membrane Remodeling · 16 genes
• Epithelial Junction Integrity · 8 genes

Mitochondrial & OxPhos (11)

• Colonocyte Metabolic Defense · 9 genes
• Electron Transport Chain · 14 genes
• Metabolic Stress Response · 11 genes
• Mitochondrial Biogenesis · 12 genes
• Mitochondrial Biogenesis · 13 genes
• Mitochondrial Homeostasis · 8 genes
• Mitochondrial Metabolism · 10 genes
• Mitochondrial OxPhos · 8 genes
• Mitochondrial OxPhos · 8 genes
• Oxidative Phosphorylation · 12 genes
• Oxidative Phosphorylation · 10 genes

Mucus production & secretion (9)

• Goblet Cell Identity · 10 genes
• Goblet Secretory Identity · 17 genes
• Goblet Secretory Identity · 13 genes
• Golgi-Exocytosis Machinery · 11 genes
• Mucin Folding Machinery · 9 genes
• Mucin Glycosylation Remodeling · 8 genes
• Mucin O-Glycosylation · 17 genes
• Mucin O-Glycosylation · 10 genes
• Protein trafficking & glycosylation · 10 genes

Protein processing & ER (9)

• CCT Chaperonin Complex · 11 genes
• Co-translational Chaperone · 9 genes
• ER Chaperone Glycosylation · 13 genes
• ER Protein Processing · 9 genes
• ER Protein Translocation · 9 genes
• ER Targeting ERAD · 10 genes
• ERAD ER Homeostasis · 10 genes
• Mitochondrial Chaperone · 9 genes
• Proteasome Complex · 10 genes

RNA processing & translation (7)

• hnRNP RNA Processing · 9 genes
• mRNA Stability Control · 14 genes
• mRNA Translation Initiation · 11 genes
• RNA Decay Processing · 11 genes
• RNA Splicing · 8 genes
• Spliceosome Assembly · 17 genes
• SR Splicing Factors · 10 genes

Stress (12)

• DUOX2 Epithelial Inflammation · 10 genes
• Glutathione Detoxification · 10 genes
• Heat Shock Response · 14 genes
• Hypoxia Metabolic Stress · 9 genes
• Inflammatory Goblet Remodeling · 12 genes
• N-Glycosylation ER Stress · 8 genes
• NF-κB Stress Response · 10 genes
• Nucleotide Metabolism Stress · 8 genes
• Pyroptosis Stress Response · 15 genes
• S100 Calcium Signaling · 13 genes
• Stress Survival Response · 12 genes
• UPR Chaperone Response · 11 genes