Secretory Lineage Specification
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 21 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes ATOH1 (master secretory lineage TF), DLL1 (Notch ligand), LFNG (Notch modulator), HES6 (Notch effector), NEURL1 (Notch regulator), and FOXA2 (secretory pioneer TF) collectively define a Notch-driven secretory cell fate specification program. RAB26 links to secretory vesicle function, CBFA2T2 to differentiation control. This is a well-characterized intestinal secretory lineage commitment program operating in goblet cell progenitors. Significant upregulation with CD treatment suggests restoration of normal epithelial differentiation.
Genes
ANXA13, ATOH1, CA8, CBFA2T2, DLL1, DYRK4, FOXA2, FRA10AC1, GSE1, GUCA2A, HES6, HPCAL1, HSD11B2, KIF19, LFNG, MDK, NECTIN1, NEURL1, RAB26, RNASE1, TMEM61
Most correlated modules
- Mucin O-Glycosylation · correlation 0.71
- Goblet Cell Identity · correlation 0.66
- BMP Signaling Response · correlation 0.59
- Goblet Secretory Identity · correlation 0.52
- RNA Splicing · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.