C4BPA — Complement component 4 binding protein alpha
C4BPA belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C4BPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Hypoxia-Inflammatory Reprogramming Inflammation | ANGPTL4, CARHSP1, ENKUR, ERO1A, FAXDC2, ITGB6, LYPD5, MXRA5 +11 more | View in SCUBA |
About the gene
| Synonyms | C4BP |
|---|---|
| Chromosome | 1: 207104233-207144972 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Biological process | Complement pathway, Immunity, Innate immunity |
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.