MXRA5 — Matrix remodeling associated 5
MXRA5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MXRA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A +7 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADAMDEC1, EDIL3, EMID1, FOXF1, IL1R1, LRP1, LTBP4, NR2F1 +2 more | View in SCUBA |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GAS6, GJA1, MAP1LC3A, PHF14, PLAU, POSTN +1 more | View in SCUBA |
About the gene
| Synonyms | DKFZp564I1922 |
|---|---|
| Chromosome | X: 3308565-3346652 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted secreted proteins |
Function
In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.