Hypoxia-Inflammatory Reprogramming
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
This module is enriched in inf_colono and significantly upregulated in both UC and CD inflammation, with reversal at UC remission. Hub genes include NOS2 (inducible nitric oxide synthase, canonical inflammatory/hypoxic response), TGM2 (transglutaminase 2, inflammation/fibrosis), ERO1A (ER oxidoreductase, ER stress/hypoxia), PFKFB3 (glycolytic enzyme, hypoxia/Warburg effect), ANGPTL4 (hypoxia-inducible, angiogenesis), SAA2 (serum amyloid A2, acute phase), ZBP1 (Z-DNA binding protein, innate immune/necroptosis), ITGB6 (integrin beta-6, TGF-beta activation/wound healing), P4HA1 (prolyl hydroxylase, collagen/hypoxia), MXRA5 (matrix remodeling). The co-occurrence of NOS2, PFKFB3, ERO1A, and ANGPTL4 strongly points to a hypoxia-driven inflammatory metabolic reprogramming program, with additional ER stress and matrix remodeling components.
Genes
Most correlated modules
- IFN-γ Antiviral Response · correlation 0.88
- IFN-gamma Response · correlation 0.88
- Oxidative Inflammatory Remodeling · correlation 0.86
- Basement Membrane Remodeling · correlation 0.85
- Epithelial Innate Immunity · correlation 0.84
- Wound Regenerative Response · correlation 0.76
- MHC II Antigen Presentation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.