ANGPTL4 — Angiopoietin like 4
ANGPTL4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANGPTL4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Inflammatory Activation Response Inflammation | C11orf96, CD83, CEBPD, ENY2, GEM, IDI1, IRF9, LMO4 +3 more | View in SCUBA |
About the gene
| Synonyms | ARP4, FIAF, HFARP, NL2, PGAR, pp1158 |
|---|---|
| Chromosome | 19: 8363289-8374370 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Lipid metabolism |
Function
Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis (By similarity). Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.