CACNA2D2 — Calcium voltage-gated channel auxiliary subunit alpha2delta 2
CACNA2D2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNA2D2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | ARHGAP26, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19, NBPF20 +10 more |
About the gene
| Synonyms | alpha2delta-2, KIAA0558 |
|---|---|
| Chromosome | 3: 50362613-50504244 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.