TCR-Cytokine Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
RASGRP1 is a critical Ras guanyl nucleotide exchange factor downstream of the TCR, essential for T cell activation. NFATC2 is a canonical TCR-downstream transcription factor. SMAD3 mediates TGF-β signaling, while STAT5B transduces cytokine (IL-2/IL-15) signals important for γδ T cell homeostasis. PIAS2 modulates STAT/SMAD activity via SUMOylation. ARHGAP26 and CCDC88C regulate cytoskeletal/Wnt pathways downstream of TCR. PPP2R5A and TAOK3 are regulatory kinase/phosphatase components. Together this represents a TCR-downstream and cytokine integration signaling module.
Genes
ARHGAP26, CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19, NBPF20, NFATC2, PIAS2, PPP2R5A, RAP2B, RASGRP1, SMAD3, STAT5B, TAOK3, WDTC1, ZBTB44
Most correlated modules
- γδ T Cell Identity · correlation 0.87
- Immune Synapse Cytoskeleton · correlation 0.85
- TGF-β Migration Program · correlation 0.84
- Coinhibitory Checkpoint · correlation 0.84
- Naive T cell quiescence · correlation 0.83
- Cytotoxic Effector Program · correlation 0.81
- TCR Proximal Signaling · correlation 0.81
- TGF-beta Signaling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.