ARHGAP26 — Rho GTPase activating protein 26
ARHGAP26 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP26's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL33 Alarmin Signaling Inflammation | CHN1, DOC2B, IL33, MCUB, PTAFR, SDCBP, SLC8A1, STMN3 +1 more | View in SCUBA |
| Enterocytes | YAP cytoskeletal remodeling Migration & adhesion | ABLIM1, AHCYL2, CCSER1, CDC42BPA, FGD4, ITGB8, PDE4D, PIP5K1B +5 more | View in SCUBA |
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | CACNA2D2, CCDC88C, LPGAT1, LY75, MED15, NBPF14, NBPF19, NBPF20 +10 more | |
| Macrophages | MAPK Stress Kinase Inflammatory | BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1, FOXK2 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immune Synapse Signaling TCR Signaling | APC, ASXL2, CD46, CPSF2, DOCK8, EEA1, EIF4G3, EPB41 +21 more |
About the gene
| Synonyms | GRAF, KIAA0621, OPHN1L, OPHN1L1 |
|---|---|
| Chromosome | 5: 142770377-143229011 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.