CCDC88C — Coiled-coil domain containing 88C
CCDC88C belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC88C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, BROX, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB, KMT2C +4 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | ABR, AIF1L, ASS1, CPNE8, EPHA4, IFITM2, MOB2, RAB30 +5 more | View in SCUBA |
| Gamma-delta T cells | TCR-Cytokine Signaling TCR Signaling | ARHGAP26, CACNA2D2, LPGAT1, LY75, MED15, NBPF14, NBPF19, NBPF20 +10 more | |
| Mucosal-associated invariant T cell | TCR Activation Signaling TCR Signaling | ARFGEF1, ARIH1, CARD11, CD226, GLS, KANSL1, KMT5B, MAP3K2 +12 more |
About the gene
| Synonyms | DAPLE, HkRP2, KIAA1509, SCA40 |
|---|---|
| Chromosome | 14: 91271323-91417844 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Wnt signaling pathway |
Function
Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling. Promotes apical constriction of cells via ARHGEF18
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.