CACNB3 — Calcium voltage-gated channel auxiliary subunit beta 3
CACNB3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | RNA Splicing Processing RNA processing & translation | ADAT2, ARHGEF40, ARHGEF9, BAIAP3, D2HGDH, DGLUCY, FN3K, KRI1 +4 more | View in SCUBA |
About the gene
| Synonyms | CACNLB3 |
|---|---|
| Chromosome | 12: 48813794-48828941 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, FDA approved drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.