D2HGDH — D-2-hydroxyglutarate dehydrogenase
D2HGDH belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
D2HGDH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | RNA Splicing Processing RNA processing & translation | ADAT2, ARHGEF40, ARHGEF9, BAIAP3, CACNB3, DGLUCY, FN3K, KRI1 +4 more | View in SCUBA |
About the gene
| Synonyms | D2HGD, FLJ42195, MGC25181 |
|---|---|
| Chromosome | 2: 241734602-241768816 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.