RNA Splicing Processing
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Low-expression core module with genes spanning RNA splicing (SNRNP70, PRPF40B, ADAT2), tRNA modification (ADAT2), mitochondrial ribosome assembly (METTL17), and ribosome biogenesis (KRI1), with slight crypt colonocyte enrichment. Despite functional heterogeneity, the RNA processing sub-theme is the most coherent biological program represented.
Genes
Most correlated modules
- Transcription-Coupled Splicing · correlation 0.90
- Pre-mRNA Splicing · correlation 0.86
- ER Stress & Lipid Metabolism · correlation 0.86
- Spliceosome Assembly · correlation 0.79
- Stress RNA Methylation · correlation 0.78
- Crypt Colonocyte Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.