CARMIL2 — Capping protein regulator and myosin 1 linker 2
CARMIL2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CARMIL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | ATXN2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2, PTEN +8 more |
About the gene
| Synonyms | LRRC16C, RLTPR |
|---|---|
| Chromosome | 16: 67644988-67657569 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
Function
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.