PI3K-AKT Regulation
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence and a heterogeneous gene set. Top hub PTEN is a phosphatase that antagonizes PI3K/AKT signaling, critical for T cell homeostasis and survival. USP25 is a deubiquitinase involved in NF-κB and immune signaling. CARMIL2 (RLTPR) is essential for TCR-CD28 costimulatory signaling. KMT2A is a histone methyltransferase (chromatin/epigenetic regulation). STT3B is involved in N-glycosylation in the ER. ERO1A is an ER oxidoreductase. GRAMD1A is involved in lipid transfer. SINHCAF is a transcriptional repressor. The module combines PI3K/AKT pathway regulation (PTEN), TCR costimulation (CARMIL2), chromatin regulation (KMT2A, SINHCAF), and ER function, consistent with a broad T cell homeostasis and signaling regulation program. The moderate coherence reflects this mixed composition.
Genes
ATXN2, CARMIL2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2, PTEN, SH2D3A, SINHCAF, SPECC1L, STT3B, TMED4, TUT4, USP25, ZNF652
Most correlated modules
- TCR Signal Regulation · correlation 0.69
- Redox Stress Response · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.