ATXN2 — Ataxin 2
ATXN2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATXN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | CARMIL2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2, PTEN +8 more | |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, BAZ2B, BLTP1, BRWD1, CELF2, CEP350 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear regulatory housekeeping Housekeeping | BAZ1B, CCDC90B, CD164, CREB1, GIGYF2, HELB, HNRNPA2B1, PHIP +6 more |
About the gene
| Synonyms | ATX2, SCA2, TNRC13 |
|---|---|
| Chromosome | 12: 111443485-111599676 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.