GRAMD1A — GRAM domain containing 1A
GRAMD1A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRAMD1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, HDAC1, IGF2R, LAMB1, LGMN +11 more | View in SCUBA |
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | ATXN2, CARMIL2, ERO1A, KMT2A, LARP4B, NIN, PCNX2, PTEN +8 more | |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DCTN2, DEF6, GRHPR, HSD17B12, HSPB1, ILK, KDELR1 +11 more | View in SCUBA |
| Neutrophils | NF-κB Activation Inflammatory | EHD1, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK, PLK3 +6 more | |
| Pericytes | G1 Cell Cycle Entry Cell cycle | CCND3, CCNY, CPNE8, FKBP9, LIPA, MAPK3, MGAT1, NCK1 +6 more | View in SCUBA |
About the gene
| Synonyms | FLJ90346, KIAA1533 |
|---|---|
| Chromosome | 19: 34994784-35026471 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Autophagy, Lipid transport, Transport |
Function
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol- binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol- transfer activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.