CDKN2A — Cyclin dependent kinase inhibitor 2A
CDKN2A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDKN2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CLEC7A, INPP1, MAP3K5, N4BP1, PBXIP1 +8 more | View in SCUBA |
| Gamma-delta T cells | G1/S Entry Cell cycle | CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2, MAPK9 +15 more |
About the gene
| Synonyms | ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, P16-INK4A, p16INK4a, p19, p19Arf |
|---|---|
| Chromosome | 9: 21967752-21995301 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Apoptosis, Cell cycle, rRNA processing, Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.