H2AZ1 — H2A.Z variant histone 1
H2AZ1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AZ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | G1/S Entry Cell cycle | CDKN2A, CKS2, CMC2, H2AZ2, HMGB2, IFI27L1, KPNA2, MAPK9 +15 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5MF, H4C3, INO80E, LYPLA2, NDUFA3, NDUFB1, SEM1, SGSM3 +3 more | |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | ARF5, C17orf49, DDOST, GNB2, H2AX, H2AZ2, IFT25, MACROH2A1 +2 more | View in SCUBA |
| Smooth muscle cells | Histone Variant Chromatin DNA/chromatin regulation | ATP5MJ, ATP5MK, ECRG4, H2AZ2, H3-3A, H3-3B, MACROH2A1, MICOS10 +6 more | View in SCUBA |
About the gene
| Synonyms | H2A.Z, H2AFZ, H2AZ |
|---|---|
| Chromosome | 4: 99948086-99950355 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.