G1/S Entry
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 24 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes TUBA1C (alpha-tubulin, highly expressed in proliferating cells), CKS2 (CDK regulatory subunit, S/G2/M), PTTG1 (securin, sister chromatid separation at metaphase-anaphase transition), H2AZ1/H2AZ2 (histone variant H2A.Z, marks active/poised chromatin at replication origins), RBBP8 (CtIP, DNA end resection/S-phase checkpoint), RAN (GTPase critical for mitotic spindle), HMGB2 (chromatin architectural protein, elevated in proliferating cells), KPNA2 (importin-alpha, mitotic nuclear transport), NASP (histone chaperone, H3.1 deposition S-phase), RFC2 neighbor/RFC2 (replication), SLC25A5 (ADP/ATP translocase, mitochondria), SPINDOC (PP1 regulatory subunit), TUBA1B (alpha-tubulin), RHEB (mTORC1 activator), PPIF (cyclophilin D/mitochondria), MPC2 (mitochondrial pyruvate carrier). This module captures early-to-mid cell cycle (G1/S entry and G2) with chromatin remodeling and cytoskeletal/tubulin components. Coherence is strong. Neighboring M183 (MCM/replication initiation) and M88 (late mitosis) bracket this as an early-cycle program.
Genes
CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2, MAPK9, MPC2, NASP, PPIF, PTMA, PTTG1, RAN, RBBP8, RFC2, RHEB, SIVA1, SLC25A5, SPATA2, SPINDOC, TUBA1B, TUBA1C
Most correlated modules
- S-phase Replication · correlation 0.84
- Mitochondrial ETC · correlation 0.82
- Mitosis Execution · correlation 0.81
- snRNP Splicing · correlation 0.80
- Basal Lipid Metabolism · correlation 0.80
- S-phase Proliferation · correlation 0.78
- DNA Replication Licensing · correlation 0.76
- Pre-mRNA Splicing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.