CEP164 — Centrosomal protein 164
CEP164 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CEP164's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Stress RNA Methylation Stress | AJM1, ARHGEF38, ASXL1, ATF5, ATF7IP2, CBX4, EIF4A1, FAM53C +19 more | View in SCUBA |
About the gene
| Synonyms | KIAA1052, NPHP15 |
|---|---|
| Chromosome | 11: 117314557-117413266 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Cilium biogenesis/degradation, DNA damage, DNA repair, Mitosis |
Function
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.