ATF7IP2 — Activating transcription factor 7 interacting protein 2
ATF7IP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATF7IP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MAEA, MGAT1 +7 more | View in SCUBA |
| Gamma-delta T cells | T Cell Development T cell maturation | ANK3, CERK, ERN1, FKBP11, LRIG1, MICAL2, PAG1, PBXIP1 +4 more | |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ADI1, ARID1B, CFAP298, EIF2AK2, HNRNPH3, MINDY2, MPC2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Regulation DNA/chromatin regulation | CHD6, KLF3, LYST, NLRP1, OSBPL8, P2RY8, SF3B6, SNU13 +1 more |
About the gene
| Synonyms | FLJ12668 |
|---|---|
| Chromosome | 16: 10326434-10483638 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.