Stress RNA Methylation

Gene co-expression module in Colonocytes

View this module in SCUBA

Why this annotation

Hub gene SERPINH1 (HSP47) is a collagen-specific chaperone and heat shock protein upregulated under ER/proteotoxic stress. MAT2A encodes methionine adenosyltransferase 2A, the enzyme producing S-adenosylmethionine (SAM), the universal methyl donor — linking to METTL16 (m6A RNA methyltransferase) and TRNT1 (tRNA CCA-adding enzyme). SRSF7, PCF11, ZNF830, ICE2 are splicing/RNA processing factors. EIF4A1 is a translation initiation helicase. ASXL1 and CBX4 are Polycomb chromatin regulators. NEK8 is a kinase involved in DNA replication stress. The co-expression of SERPINH1 with RNA methylation (METTL16, MAT2A) and splicing factors suggests a stress-associated RNA regulatory state, possibly reflecting a proteotoxic/ER stress response that co-activates RNA processing remodeling. Negative delta_treatment_CD suggests suppression by treatment.

Genes

Most correlated modules

• Transcription-Coupled Splicing · correlation 0.85
• RNA Splicing Processing · correlation 0.78
• P-TEFb Transcription Control · correlation 0.77
• Dissociation Stress Artifact · correlation 0.75
• ER Stress & Lipid Metabolism · correlation 0.74
• Integrated Stress Response · correlation 0.56

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.