CHML — CHM like Rab escort protein
CHML belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHML's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, ATP6V0A1, CHFR, FAR1, FBXL5, GSAP, HAPSTR1 +21 more | View in SCUBA |
About the gene
| Synonyms | REP-2 |
|---|---|
| Chromosome | 1: 241628851-241640369 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | GTPase activation |
Function
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.