FAR1 — Fatty acyl-CoA reductase 1
FAR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling DNA/chromatin regulation | ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FLII, HCFC1 +17 more | |
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, ATP6V0A1, CHFR, CHML, FBXL5, GSAP, HAPSTR1 +21 more | View in SCUBA |
| Neutrophils | Neutrophil Differentiation Developmental | DACH1, DGKD, MPP7, MSRA, PAM, PLCL2, PTBP2, RELL1 +1 more |
About the gene
| Synonyms | FLJ22728, MLSTD2, SDR10E1 |
|---|---|
| Chromosome | 11: 13668668-13732346 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.