ATP6V0A1 — ATPase H+ transporting V0 subunit a1
ATP6V0A1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V0A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, DGKD, IL4R, ITPR1 +9 more | View in SCUBA |
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, CHFR, CHML, FAR1, FBXL5, GSAP, HAPSTR1 +21 more | View in SCUBA |
About the gene
| Synonyms | a1, ATP6N1, ATP6N1A, Stv1, Vph1, VPP1 |
|---|---|
| Chromosome | 17: 42458844-42522582 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.