Endolysosomal Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include FAR1 (ether lipid/fatty alcohol synthesis), LPGAT1 (lysophospholipid acyltransferase), SFXN3 (mitochondrial sideroflexin), VMP1 (autophagy/ER-lipid droplet contact sites), ATP6V0A1 (lysosomal V-ATPase subunit), VPS8 (CORVET endosomal tethering), PDCD6IP/ALIX (ESCRT-III), and STT3B (N-glycosylation). Strong mono_mac enrichment for multiple genes. The module combines lipid metabolism (FAR1, LPGAT1) with endolysosomal/vesicular trafficking (VPS8, PDCD6IP, ATP6V0A1, VMP1), which are functionally linked in macrophage phagolysosomal biology. The dominant program is endolysosomal vesicular trafficking with lipid remodeling, consistent with monocyte-derived macrophage identity.
Genes
ANKRD10, ATP1A1, ATP6V0A1, CHFR, CHML, FAR1, FBXL5, GSAP, HAPSTR1, LPCAT2, LPGAT1, MAP3K2, MAPK1, NPEPPS, OTUD4, PDCD6IP, PRKAA1, SCYL2, SFXN3, STT3B, STX12, TM2D1, TMEM51, UBA6, UEVLD, UNC13D, VEZT, VHL, VMP1, VPS8
Most correlated modules
- Endolysosomal Trafficking · correlation 0.97
- ER-Golgi Trafficking · correlation 0.97
- RAB-mediated Trafficking · correlation 0.96
- ER Membrane Homeostasis · correlation 0.95
- RNA Processing Housekeeping · correlation 0.95
- Sphingolipid Membrane Homeostasis · correlation 0.95
- RNA Processing Transport · correlation 0.95
- Chromatin Transcriptional Regulation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.