CHRDL2 — Chordin like 2
CHRDL2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHRDL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CDON, CFB, CLU, FAM20A, MID1, RARRES1, STEAP2 | View in SCUBA |
About the gene
| Synonyms | BNF1 |
|---|---|
| Chromosome | 11: 74696429-74731426 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.