FAM20A — FAM20A golgi associated secretory pathway pseudokinase
FAM20A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAM20A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FOXP1, FZD6, GCHFR, GIPC2 +19 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CDON, CFB, CHRDL2, CLU, MID1, RARRES1, STEAP2 | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Monocytes | Non-canonical NF-κB Innate immunity | AMPD2, BCL3, BEST1, DENND5A, NFKB2, NOCT, RELB, TICAM1 | View in SCUBA |
About the gene
| Synonyms | DKFZp434F2322 |
|---|---|
| Chromosome | 17: 68535113-68601367 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Biomineralization |
Function
Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.