CLU — Clusterin
CLU belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TGF-beta response Intercellular communication | COA1, ELK4, GLUL, GPR18, HDGFL3, ORAI2, RAB27B, RASSF2 +3 more | View in SCUBA |
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR, GIPC2 +19 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CDON, CFB, CHRDL2, FAM20A, MID1, RARRES1, STEAP2 | View in SCUBA |
| Glial cells | Metallothionein Stress Response Stress | CADM3, CTNNAL1, IFI35, MT1E, MT1M, MT2A, RARRES2, SERPINA5 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte Commitment Myeloid development | ARHGAP6, C2orf88, ITGA2B, MPIG6B, PPP1R14A, PRKAR2B, RGS10, RGS18 +1 more | |
| Lymphatic endothelial | Endothelial Identity endothelial development | ARL6IP5, ICAM2, LY6E, NTS, NUCB1, PLAAT4, PROCR, PSIP1 +2 more | View in SCUBA |
| Monocytes | Multi-lineage Contamination Cell contamination | AZU1, CYP19A1, E2F2, ELANE, GM2A, GYPC, ITGB7, MS4A3 +4 more | View in SCUBA |
About the gene
| Synonyms | APOJ, CLI, CLU1, CLU2, KUB1, SGP-2, SP-40, TRPM-2 |
|---|---|
| Chromosome | 8: 27596917-27614700 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Chaperone |
| Biological process | Apoptosis, Complement pathway, Immunity, Innate immunity |
Function
Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX- mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Promotes cell death through interaction with BCL2L1 that releases and activates BAX
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.