MID1 — Midline 1
MID1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MID1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MECOM, PPP1R9A, RALGAPA2 +5 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CDON, CFB, CHRDL2, CLU, FAM20A, RARRES1, STEAP2 | View in SCUBA |
About the gene
| Synonyms | FXY, OS, RNF59, TRIM18 |
|---|---|
| Chromosome | X: 10445310-10833654 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.