CLDN8 — Claudin 8
CLDN8 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLDN8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Colonocyte HOX Identity Epithelial development | B3GNT7, CAPN13, CD14, CDHR1, CKB, CRACR2A, GPR161, HOXB13 +15 more | View in SCUBA |
About the gene
| Chromosome | 21: 30214006-30216097 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion- selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity). Cannot form tight junction strands on its own
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.