Colonocyte HOX Identity
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
Module is anchored by HOXB13, HOXD11, and HOXD13 — HOX transcription factors with known roles in posterior gut/colonocyte positional identity — alongside epithelial differentiation markers: CLDN8 (tight junction, mature colonocytes), LGALS2 (galectin expressed in differentiated colonocytes), CDHR1 (cadherin-related, epithelial differentiation), QPRT (colonocyte-enriched NAD biosynthesis enzyme), SLC13A2 (dicarboxylate transporter), and RBM24 (RNA-binding protein in epithelial differentiation). B3GNT7 and ST6GAL2 are glycosyltransferases involved in epithelial glycosylation. Significantly reduced in CD inflammation. As a topological neighbor of M65 (which contains HOXA cluster genes), both modules co-express HOX positional identity programs but M130 emphasizes barrier function and transport differentiation. The shared HOX co-expression drives network proximity between the two modules.
Genes
Most correlated modules
- Mitochondrial Membrane Dynamics · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.