GPR161 — G protein-coupled receptor 161
GPR161 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR161's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Colonocyte HOX Identity Epithelial development | B3GNT7, CAPN13, CD14, CDHR1, CKB, CLDN8, CRACR2A, HOXB13 +15 more | View in SCUBA |
About the gene
| Synonyms | RE2 |
|---|---|
| Chromosome | 1: 168079542-168137667 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Function
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.