CD14 — CD14 molecule
CD14 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD99, CMTM3, DUSP3, FCGR2A, FLOT2, INF2, MARVELD1, PLAU +7 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Activation Innate immunity | AIF1, ALOX5AP, C4orf3, MCEMP1, PRELID1, SLC2A3, TIMP1, TYMP +1 more |
About the gene
| Chromosome | 5: 140631728-140633700 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Human disease related genes, Plasma proteins, Predicted secreted proteins, Transporters |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.