CLK4 — CDC like kinase 4
CLK4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Transcription/RNA processing RNA processing | ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CNOT6L, CRNKL1, ELF1 +29 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, DCP2, GPATCH2L, IL6R +20 more | View in SCUBA |
About the gene
| Chromosome | 5: 178602664-178630615 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.