BOD1L1 — Biorientation of chromosomes in cell division 1 like 1
BOD1L1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BOD1L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin & genome maintenance DNA/chromatin regulation | ARID1B, ASH1L, ATM, ATRX, DDX17, KANSL1, MARF1, NKTR +8 more | View in SCUBA |
| CD4⁺ T cells | T-cell costimulation TCR/AP1/NFKb pathway | ASH1L, CCM2, CCR4, CD28, CREBRF, DDX27, ERBIN, ICOS +10 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10, MFSD14A +13 more | |
| Lymphatic endothelial | Lymphatic Specification endothelial development | ARHGAP29, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8, MTUS1 +9 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, CCNL2, CDK12, CLK4, DCP2, GPATCH2L, IL6R +20 more | View in SCUBA |
About the gene
| Synonyms | BOD1L, FAM44A, FLJ33215, KIAA1327 |
|---|---|
| Chromosome | 4: 13568738-13627725 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | DNA damage, DNA repair |
Function
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.