mRNA Splicing Processing
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include GPATCH2L, ACIN1, RSRC2, SRRM2, PRP4K, SAFB2, SMG1, DCP2 — all involved in pre-mRNA splicing, NMD, or mRNA decay. RB1CC1 is an autophagy regulator. LYST is a lysosomal trafficking gene enriched in mono_mac. IL6R and SLC38A2 suggest some monocyte-macrophage signaling context. ARID3A and RYBP are transcription regulators. The module is weakly coherent with modest mono_mac enrichment, suggesting co-variation of large RNA-processing genes in transcriptionally active monocyte-derived macrophages. Consistent with neighbor modules M85 and M112.
Genes
ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L, IL6R, LYST, MBP, NOTCH2, PNN, PRP4K, RB1CC1, RBM23, RBM39, RSRC2, RYBP, SAFB2, SLC38A2, SMG1, SRRM2, STAG2, TAF1D, TBRG1, TCF25, UBE2R2, ZNF326
Most correlated modules
- Transcriptional Repression · correlation 0.97
- RNA Processing Housekeeping · correlation 0.96
- Chromatin Regulatory Genes · correlation 0.95
- Pre-mRNA Splicing · correlation 0.95
- Pre-mRNA Splicing · correlation 0.95
- Microtubule Organization · correlation 0.94
- Transcriptional Elongation · correlation 0.93
- Lipid-Sensing Transcriptional · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.